Sitagliptin is used as an adjunct to diet and exercise to improve glycemic control in individuals with type 2 diabetes.
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Incrit 50mg Tablet contains Sitagliptin, an anti-diabetic medication used in adults to treat type 2 diabetes either alone or in combination with other anti-diabetic drugs, diet, and exercise. Type 2 diabetes is characterized by insufficient insulin production or decreased insulin effectiveness, resulting in elevated blood glucose levels that can lead to serious health issues such as heart disease, kidney disease, and vision problems. Symptoms may include increased thirst, urination, and hunger, blurry vision, numbness in extremities, and fatigue.
Before taking Incrit 50mg Tablet, it's important to inform your doctor if you have a history of pancreas disorders, gallstones, alcohol dependence, high levels of blood fats, type 1 diabetes, diabetic ketoacidosis, or any kidney or heart conditions. This medication is not recommended during pregnancy or breastfeeding, so consult your doctor before use. Additionally, Incrit 50mg Tablet is not suitable for children and adolescents under 18 years of age.
Remember to take Incrit 50mg Tablet as prescribed by your healthcare provider and follow a comprehensive diabetes management plan that includes diet and exercise to help control your blood sugar levels effectively.
Before taking Incrit 50mg Tablet, inform your doctor if you have or had alcohol dependence.
Incrit 50mg Tablet is not recommended for use in pregnant women. Consult your doctor before taking it.
Incrit 50mg Tablet is not recommended for use in breastfeeding women as it is not known if it passes into human breast milk. Consult your doctor before taking it.
Do not drive or operate any machines if you feel dizzy or drowsy after taking Incrit 50mg Tablet.
Incrit 50mg Tablet should be used with caution in patients with kidney problems. Consult your doctor before taking it.
Incrit 50mg Tablet should be used with caution in patients with liver problems. Consult your doctor before taking it.
Incrit 50mg Tablet works by slowing down the inactivation of gut hormones released after eating the meals. This kind of action increases the secretion of insulin and decreases glucagon release (a hormone that raises blood glucose levels), resulting in an overall increase in blood glucose control.
Common side effects include headache, upper respiratory tract infection, and nasopharyngitis. Hypoglycemia may occur when sitagliptin is used in combination with sulfonylureas or insulin.
Type 2 diabetes is a condition characterized by the body's inability to produce sufficient insulin or effectively utilize the insulin it produces. This results in elevated blood sugar levels, a condition known as hyperglycemia. Common symptoms of type 2 diabetes include increased thirst, frequent nighttime urination, slow wound healing, heightened appetite, fatigue, and blurred vision. While some individuals may experience weight gain, others may undergo weight loss, albeit less commonly.
Type 2 diabetes can lead to various complications, including neuropathy (nerve damage), nephropathy (kidney dysfunction), retinopathy (damage to the eye's retina, potentially leading to blindness), limb amputation, sexual dysfunction, and an elevated risk of heart attacks or strokes. Managing type 2 diabetes typically involves a combination of medication, lifestyle changes such as diet and exercise, and regular monitoring to maintain healthy blood sugar levels and reduce the risk of complications.
Sitagliptin is a DPP-4 inhibitor that works in individuals with type 2 diabetes by delaying the inactivation of incretin hormones. It increases the concentrations of active intact hormones, which, in turn, enhances and prolongs their activity. Incretin hormones, such as GLP-1 and GIP, regulate glucose homeostasis in the body. Sitagliptin helps increase insulin production and release from pancreatic beta cells, inhibits the release of glucagon by pancreatic alpha cells, and lowers hepatic glucose synthesis in a glucose-dependent manner. It achieves this by raising and extending active incretin levels.
Sitagliptin does not significantly affect the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, warfarin, or oral contraceptives. It slightly increases the mean concentration of Digoxin, but no dose adjustment is required for either drug.
Sitagliptin should not be used in individuals with a history of allergic reactions to sitagliptin, including anaphylaxis or angioedema.
Sitagliptin is classified as Pregnancy Category B. While animal reproduction studies have been conducted, this medication should only be used during pregnancy if absolutely necessary. Sitagliptin is excreted in rat milk but is not known to be excreted in human milk, so caution is advised when prescribing to breastfeeding women.
Sitagliptin should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis as it is ineffective in these conditions. The safety and effectiveness of sitagliptin in individuals with a history of pancreatitis have not been established.
Store sitagliptin below 25°C in a dry place away from light. Keep it out of the reach of children and do not use it beyond the expiration date. Dispense only on a qualified physician's prescription.
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